Gene: Lrp1

Order

Name low density lipoprotein receptor-related protein 1

Synonyms
  • CD91
  • A2mr
  • b2b1554Clo

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:96828    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Lrp1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Lrp1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal embryo size Lrp1tm1.1(KOMP)Wtsi HOM embryonic day 12.5 0.0
abnormal limb bud morphology Lrp1tm1.1(KOMP)Wtsi HOM embryonic day 12.5 0.0
abnormal pericardium morphology Lrp1tm1.1(KOMP)Wtsi HOM embryonic day 12.5 0.0
pallor Lrp1tm1.1(KOMP)Wtsi HOM embryonic day 12.5 0.0
preweaning lethality, complete penetrance Lrp1tm1.1(KOMP)Wtsi HOM Female Male n/a 0.0
abnormal sleep behavior Lrp1tm1.1(KOMP)Wtsi HET Female Male postnatal 4.44E-6
cardiovascular system phenotype Lrp1tm1.1(KOMP)Wtsi HET Female Male postnatal 3.01E-5
decreased exploration in new environment Lrp1tm1.1(KOMP)Wtsi HET Female Male postnatal 3.3E-5
decreased heart rate variability Lrp1tm1.1(KOMP)Wtsi HET Female Male postnatal 4.86E-5
shortened PQ interval Lrp1tm1.1(KOMP)Wtsi HET Female Male postnatal 9.56E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393) (2/2)
Aorta 2 No (1/562) (2/2)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562) (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562) (2/2)
Cerebellum 2 No (4/562) (2/2)
Cerebral cortex 2 No (5/562) (2/2)
Epididymis 2 No (4/106) (1/2)
Esophagus 2 No (2/393) (2/2)
Eye 2 No (1/562) (2/2)
Heart 2 No (3/562) (2/2)
Hippocampus 2 No (5/562) (2/2)
Hypothalamus 2 No (4/562) (2/2)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562) (2/2)
Liver 2 No (2/2)
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562) (2/2)
Lymph node 2 No (1/562) (2/2)
Mammary gland 2 No (1/2)
Midbrain 2 No (2/2)
Olfactory lobe 2 No (4/393) (2/2)
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562) (2/2)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562) (2/2)
Prostate gland 2 No (5/562)
Skeletal muscle 2 No
Skin 2 No (1/562) (2/2)
Small intestine 2 No (11/562) (2/2)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562) (2/2)
Stomach 2 No (9/562) (2/2)
Striatum 2 No (4/562) (2/2)
Submandibular gland 2 No (1/104) (2/2)
Testis 2 No (4/562) (1/2)
Thalamus 2 No (2/2)
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562) (2/2)
Urinary bladder 2 No (2/2)
Uterus 2 No (2/562) (1/2)
Vascular system 2 No (1/393) (2/2)
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/482) (1/3)
Dorsal root ganglion 1 (1/45)
Ear 2 (1/482)
Embryo 2 (1/482) (2/3)
Eye 2 (1/482)
Foot 2 (1/482)
Forebrain 2 (1/482)
Forelimb 2 (1/482)
Fronto-nasal process 1 (1/46) Image Only
Hand 2 (1/482)
Head 2 (5/482) (2/3)
Heart 2 (1/482)
Hindbrain 2 (6/482) (1/3)
Hindlimb 2 (1/482)
Liver 2 (1/482)
Lung 2 (1/482)
Mandibular process 2 (1/482)
Maxillary process 2 (1/482)
Midbrain 2 (1/482)
Nose 1 (1/47)
Oral cavity 2 (1/482)
Skin 2 (1/482) (1/3)
Spinal cord 1 (1/46)
Tail 2 (1/482)
Tail somite 2 (1/482)


Associated Images

Associated Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • X-ray: XRay Images Forepaw
    10 Images
  • X-ray: XRay Images Skull Lateral Orientation
    10 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • Sleep Wake: Wake state (bmp file)
    11 Images
  • Combined SHIRPA and Dysmorphology
    8 Images
  • Eye Morphology: Images Slit Lamp
    2 Images
  • Embryo LacZ: LacZ images wholemount
    12 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Lrp1tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Lrp1tm1.1(KOMP)Wtsi Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene