Gene: Il6st

Order

Name interleukin 6 signal transducer

Synonyms
  • CD130
  • gp130
  • D13Ertd699e
  • 5133400A03Rik

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:96560    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Il6st

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Il6st data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Il6sttm1b(KOMP)Mbp HOM Female Male n/a 0.0
increased bone mineral density Il6sttm1b(KOMP)Mbp HOM Female Male postnatal 9.74E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (5/393) (4/4)
Aorta 4 No (1/562) (4/4)
Bone 2 No (1/539) (2/2)
Bone marrow 2 No (2/2)
Brain 4 No (6/562) (4/4)
Brainstem 4 No (4/562) (4/4)
Brown adipose tissue 4 No (4/4)
Cartilage tissue 4 No (1/562) (4/4)
Cerebellum 4 No (4/562) (4/4)
Cerebral cortex 4 No (5/562) (4/4)
Epididymis 4 No (4/106) (2/4)
Esophagus 4 No (2/393) (4/4)
Eye 4 No (1/562) (4/4)
Heart 4 No (3/562) (4/4)
Hippocampus 4 No (5/562) (4/4)
Hypothalamus 4 No (4/562) (4/4)
Kidney 4 No (20/562) (4/4)
Large intestine 4 No (12/562) (4/4)
Liver 4 No (4/4)
Lower urinary tract 4 No (3/562)
Lung 4 No (3/562) (4/4)
Lymph node 4 No (1/562) (4/4)
Mammary gland 4 No (2/4)
Midbrain 4 No (4/4)
Olfactory lobe 4 No (4/393) (4/4)
Ovary 4 No (1/562) (2/4)
Oviduct 4 No (2/562) (2/4)
Pancreas 4 No (6/562) (4/4)
Peripheral nervous system 4 No (3/562) (4/4)
Peyer's patch 4 No (1/393) (2/4)
Pituitary gland 4 No (1/562) (4/4)
Prostate gland 4 No (5/562)
Skeletal muscle 4 No (2/4)
Skin 4 No (1/562) (4/4)
Small intestine 4 No (11/562) (4/4)
Spinal cord 4 No (3/562) (4/4)
Spleen 4 No (4/562) (4/4)
Stomach 4 No (9/562) (4/4)
Striatum 4 No (4/562) (2/4)
Submandibular gland 3 No (1/104) (3/3)
Testis 4 No (4/562) (2/4)
Thalamus 4 No (4/4)
Thymus 4 No (4/4)
Thyroid gland 4 No (16/562) (4/4)
Trachea 4 No (3/562) (4/4)
Urinary bladder 4 No (4/4)
Uterus 4 No (2/562) (2/4)
Vascular system 4 No (1/393) (4/4)
Vesicular gland 4 No
White adipose tissue 4 No (4/4)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    adipose tissue
    musculoskeletal system
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/482) (2/3)
Dorsal root ganglion 2 (1/45) Image Only
Ear 2 (1/482) Image Only
Embryo 2 (1/482) (2/3)
Eye 2 (1/482) (2/3)
Foot 2 (1/482) (2/3)
Forebrain 2 (1/482) (2/3)
Forelimb 2 (1/482) (2/3)
Fronto-nasal process 2 (1/46) Image Only
Hand 2 (1/482) (2/3)
Head 2 (5/482) (2/3)
Heart 2 (1/482) (2/3)
Hindbrain 2 (6/482) (2/3)
Hindlimb 2 (1/482) (2/3)
Liver 2 (1/482)
Lung 2 (1/482) Image Only
Mandibular process 2 (1/482) (2/3)
Maxillary process 2 (1/482) (2/3)
Midbrain 2 (1/482) (2/3)
Nose 2 (1/47) (2/3)
Oral cavity 2 (1/482) Image Only
Skin 2 (1/482) (2/3)
Spinal cord 2 (1/46) (2/3)
Tail 2 (1/482) (2/3)
Tail somite 2 (1/482) (2/3)


Associated Images

Associated Images
  • Sleep Wake: Wake state (bmp file)
    14 Images
  • X-ray: XRay Images Lateral Orientation
    12 Images
  • X-ray: XRay Images Dorso Ventral
    12 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    12 Images
  • X-ray: XRay Images Skull Lateral Orientation
    12 Images
  • Embryo LacZ: LacZ images wholemount
    12 Images
  • Combined SHIRPA and Dysmorphology
    3 Images
  • X-ray: XRay Images Forepaw
    12 Images
  • Eye Morphology: Images Slit Lamp
    2 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Il6sttm1b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Il6sttm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene