Gene: Aurka

Order

Name aurora kinase A

Synonyms
  • aurora A
  • Aurora-A
  • IAK1
  • Stk6
  • AIRK1
  • IAK
  • Ark1
  • Ayk1

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:894678    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Aurka

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Aurka data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal embryo size Aurkatm1b(EUCOMM)Hmgu HET Female embryonic day 9.5 0.0
abnormal embryo turning Aurkatm1b(EUCOMM)Hmgu HET Female Male embryonic day 9.5 0.0
embryonic growth retardation Aurkatm1b(EUCOMM)Hmgu HET Female embryonic day 9.5 0.0
embryonic lethality prior to tooth bud stage Aurkatm1b(EUCOMM)Hmgu HOM Female Male embryonic day 12.5 0.0
preweaning lethality, complete penetrance Aurkatm1b(EUCOMM)Hmgu HOM Female Male n/a 0.0
increased mean corpuscular hemoglobin Aurkatm1b(EUCOMM)Hmgu HET Female Male postnatal 2.18E-5
sclerocornea Aurkatm1b(EUCOMM)Hmgu HET Female postnatal 6.35E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415) (2/2)
Aorta 2 No
Bone marrow 2 No (1/2)
Brain 2 No
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No
Cerebral cortex 2 No
Epididymis 2 No (18/134) (1/2)
Esophagus 2 No (7/415) (2/2)
Eye 2 No (1/2)
Heart 2 No
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Midbrain 2 No
Olfactory lobe 2 No
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584) (1/2)
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No (1/2)
Prostate gland 2 No (12/584)
Skeletal muscle 2 No
Skin 2 No
Small intestine 2 No (9/584) (1/2)
Spinal cord 2 No
Spleen 2 No (2/584)
Stomach 2 No (12/584) (1/2)
Striatum 2 No
Submandibular gland 2 No (2/132) (2/2)
Testis 2 No (2/584) (1/2)
Thalamus 2 No
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No
Urinary bladder 2 No (2/2)
Uterus 2 No (1/2)
Vascular system 2 No
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    postnatal mouse
    respiratory system
    digestive system
    nervous system
    sensory organ
    reproductive system
    musculoskeletal system
    immune system
    exocrine system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/485) (2/2)
Dorsal root ganglion 1 (1/47) Image Only
Ear 2 (1/485) (2/2)
Embryo 2 (1/485) (2/2)
Eye 2 (1/485) (2/2)
Foot 2 (1/485) (2/2)
Forebrain 2 (1/485) (2/2)
Forelimb 2 (1/485) (2/2)
Fronto-nasal process 1 (1/48) Image Only
Hand 2 (1/485) (2/2)
Head 2 (5/485) (2/2)
Heart 2 (1/485) (2/2)
Hindbrain 2 (6/485) (2/2)
Hindlimb 2 (1/485) (2/2)
Liver 2 (1/485)
Lung 2 (1/485) (1/2)
Mandibular process 2 (1/485) (2/2)
Maxillary process 2 (1/485) (2/2)
Midbrain 2 (1/485) (2/2)
Nose 1 (1/51) (1/1)
Oral cavity 2 (1/485) (1/2)
Skin 2 (1/485) (2/2)
Spinal cord 1 (1/50) (1/1)
Tail 2 (1/485) (2/2)
Tail somite 2 (1/485) (1/2)


Associated Images

Associated Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    8 Images
  • X-ray: XRay Images Skull Lateral Orientation
    8 Images
  • Electroretinography 2: Rod and cone PDF
    4 Images
  • Embryo LacZ: LacZ images wholemount
    8 Images
  • X-ray: XRay Images Lateral Orientation
    8 Images
  • X-ray: XRay Images Forepaw
    8 Images
  • Sleep Wake: Wake state (bmp file)
    4 Images
  • X-ray: XRay Images Dorso Ventral
    8 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Aurkatm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Aurkatm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)
Vector
Gene