Gene: Kdm4b

Order

Name lysine (K)-specific demethylase 4B

Synonyms
  • Jmjd2b
  • 4732474L06Rik

Status ES CellsMice
tm1a
phenotype data available

Links MGI:2442355    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Subviable

Phenotype associations for Kdm4b

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Kdm4b data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, incomplete penetrance Kdm4btm1a(EUCOMM)Wtsi HOM Female Male n/a 0.0
abnormal behavior Kdm4btm1a(EUCOMM)Wtsi HET Female Male postnatal 8.6E-8
increased circulating creatinine level Kdm4btm1a(EUCOMM)Wtsi HET Female Male postnatal 1.85E-7
decreased circulating total protein level Kdm4btm1a(EUCOMM)Wtsi HET Female Male postnatal 2.22E-5
decreased circulating serum albumin level Kdm4btm1a(EUCOMM)Wtsi HET Male postnatal 2.55E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/2)
Aorta 2 No (1/562)
Blood vessel 2 No
Bone 2 No (1/539) (2/2)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562) (2/2)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Eye 2 No (1/562) (2/2)
Gall bladder 2 No (2/2)
Heart 2 No (3/562) (2/2)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562) (2/2)
Liver 2 No (1/2)
Lower urinary tract 2 No (3/562) (2/2)
Lung 2 No (3/562) (2/2)
Lymph node 2 No (1/562) (1/2)
Mammary gland 2 No (2/2)
Esophagus 2 No (2/2)
Olfactory lobe 2 No
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562) (2/2)
Parathyroid gland 2 No (2/540) (1/2)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No (2/2)
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562) (1/2)
Skeletal muscle tissue 2 No (2/2)
Skin 2 No (1/562) (2/2)
Small intestine 2 No (11/562) (2/2)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562) (2/2)
Stomach 2 No (9/562) (2/2)
Striatum 2 No (4/562)
Testis 2 No (4/562) (1/2)
Thymus 2 No (2/2)
Thyroid gland 2 No (16/562) (1/2)
Trachea 2 No (3/562) (1/2)
Uterus 2 No (2/562) (1/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues reproductive system musculoskeletal system trunk postnatal mouse nervous system sensory organ immune system exocrine system integumental system urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (29)
  • Kdm4btm1a(EUCOMM)Wtsi
    trachea, thyroid gland, parathyroid gland, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    skeletal muscle tissue, HET, Male, WTSI

show all 29 images

trunk (19)
  • Kdm4btm1a(EUCOMM)Wtsi
    trachea, thyroid gland, parathyroid gland, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI

show all 19 images

digestive system (5)
  • Kdm4btm1a(EUCOMM)Wtsi
    large intestine, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    peyer's patch, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    oesophagus, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    gall bladder, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    gall bladder, HET, Male, WTSI
immune system (4)
  • Kdm4btm1a(EUCOMM)Wtsi
    thymus, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    lymph node, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    peyer's patch, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    spleen, HET, Female, WTSI
integumental system (3)
  • Kdm4btm1a(EUCOMM)Wtsi
    inguinal fat pad, mammary gland, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    skin, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    pinna, skin, HET, Female, WTSI
nervous system (3)
  • Kdm4btm1a(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    peripheral nervous system, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    spinal cord, HET, Male, WTSI
reproductive system (3)
  • Kdm4btm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    ovary, oviduct, uterus, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
respiratory system (3)
  • Kdm4btm1a(EUCOMM)Wtsi
    trachea, thyroid gland, parathyroid gland, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI
endocrine system (2)
  • Kdm4btm1a(EUCOMM)Wtsi
    trachea, thyroid gland, parathyroid gland, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
musculoskeletal system (2)
  • Kdm4btm1a(EUCOMM)Wtsi
    skeletal muscle tissue, HET, Male, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    bone, HET, Female, WTSI
sensory organ (2)
  • Kdm4btm1a(EUCOMM)Wtsi
    eye, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    pinna, skin, HET, Female, WTSI
urinary system (2)
  • Kdm4btm1a(EUCOMM)Wtsi
    kidney, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Male, WTSI
adipose tissue (1)
  • Kdm4btm1a(EUCOMM)Wtsi
    inguinal fat pad, mammary gland, HET, Female, WTSI
cardiovascular system (1)
  • Kdm4btm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
exocrine system (1)
  • Kdm4btm1a(EUCOMM)Wtsi
    inguinal fat pad, mammary gland, HET, Female, WTSI
set of connective tissues (1)
  • Kdm4btm1a(EUCOMM)Wtsi
    inguinal fat pad, mammary gland, HET, Female, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (307)
  • Kdm4btm1a(EUCOMM)Wtsi
    body, WT, Male, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    body, WT, Male, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    head, WT, Male, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    forearm, WT, Male, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    body, WT, Male, WTSI

show all 307 images

Brain Histopathology (18)
  • Kdm4btm1a(EUCOMM)Wtsi
    brain, WT, Male, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    WT, Male, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    WT, Male, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    WT, Male, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    WT, Male, WTSI

show all 18 images

Skin Histopathology (3)
  • Kdm4btm1a(EUCOMM)Wtsi
    back skin, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    back skin, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    back skin, HET, Female, WTSI
Eye Morphology (2)
  • Kdm4btm1a(EUCOMM)Wtsi
    eye, abnormal pupil morphology, abnormal placement of pupils, HET, Female, WTSI
  • Kdm4btm1a(EUCOMM)Wtsi
    eye, synechia, corneal opacity, abnormal pupil morphology, cornea/lens fusion, HET, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Kdm4btm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Kdm4btm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene