Gene: Dennd2d

Order

Name DENN/MADD domain containing 2D

Synonyms 2010308M01Rik

Status ES CellsMice
tm2a
Mice
tm2b
phenotype data available

Links MGI:2181193    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Subviable

Phenotype associations for Dennd2d

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Dennd2d data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, incomplete penetrance Dennd2dtm2b(KOMP)Mbp HOM Female Male n/a 0.0
abnormal bone structure Dennd2dtm2b(KOMP)Mbp HOM Female Male postnatal 5.01E-7
increased lean body mass Dennd2dtm2b(KOMP)Mbp HOM Female postnatal 4.74E-6
decreased prepulse inhibition Dennd2dtm2b(KOMP)Mbp HOM Female Male postnatal 5.59E-6
thrombocytopenia Dennd2dtm2b(KOMP)Mbp HOM Female Male postnatal 1.76E-5
abnormal behavior Dennd2dtm2b(KOMP)Mbp HET Female Male postnatal 3.22E-5
increased bone mineral content Dennd2dtm2b(KOMP)Mbp HOM Female Male postnatal 4.72E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415) (2/2)
Aorta 2 No
Bone 2 No (2/2)
Brain 2 No (2/2)
Brainstem 2 No (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (2/2)
Cerebellum 2 No (2/2)
Cerebral cortex 2 No (2/2)
Epididymis 2 No (18/134) (1/2)
Esophagus 2 No (7/415) (2/2)
Eye 2 No (2/2)
Heart 2 No
Hippocampus 2 No (2/2)
Hypothalamus 2 No (2/2)
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No (2/2)
Lower urinary tract 2 No
Lung 2 No (2/2)
Lymph node 2 No (2/2)
Mammary gland 2 No (1/2)
Midbrain 2 No (2/2)
Olfactory lobe 2 No (2/2)
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584) (2/2)
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No (2/2)
Pituitary gland 2 No (2/2)
Prostate gland 2 No (12/584)
Skeletal muscle 2 No
Skin 2 No (2/2)
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584) (2/2)
Stomach 2 No (12/584) (2/2)
Striatum 2 No (2/2)
Submandibular gland 2 No (2/132) (2/2)
Testis 2 No (2/584) (1/2)
Thalamus 2 No (2/2)
Thymus 2 No (2/2)
Thyroid gland 2 No (15/584) (2/2)
Trachea 2 No (2/2)
Urinary bladder 2 No (2/2)
Uterus 2 No (1/2)
Vascular system 2 No
Vesicular gland 2 No
White adipose tissue 2 No (2/2)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    digestive system
    set of connective tissues
    reproductive system
    adipose tissue
    musculoskeletal system
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/485)
Dorsal root ganglion 2 (1/47)
Ear 2 (1/485)
Embryo 2 (1/485)
Eye 2 (1/485)
Foot 2 (1/485)
Forebrain 2 (1/485)
Forelimb 2 (1/485)
Fronto-nasal process 2 (1/48)
Hand 2 (1/485)
Head 2 (5/485)
Heart 2 (1/485)
Hindbrain 2 (6/485)
Hindlimb 2 (1/485)
Liver 2 (1/485)
Lung 2 (1/485)
Mandibular process 2 (1/485)
Maxillary process 2 (1/485)
Midbrain 2 (1/485)
Nose 2 (1/51)
Oral cavity 2 (1/485)
Skin 2 (1/485)
Spinal cord 2 (1/50)
Tail 2 (1/485)
Tail somite 2 (1/485)


Associated Images

Associated Images
  • X-ray: XRay Images Skull Lateral Orientation
    24 Images
  • X-ray: XRay Images Forepaw
    24 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    24 Images
  • X-ray: XRay Images Lateral Orientation
    24 Images
  • X-ray: XRay Images Dorso Ventral
    24 Images
  • Sleep Wake: Wake state (bmp file)
    6 Images
  • Combined SHIRPA and Dysmorphology
    3 Images
  • Electroretinography 2: Rod and cone PDF
    6 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Dennd2dtm2a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Dennd2dtm2b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Dennd2dtm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Dennd2dtm41823(L1L2_gt0)
Vector
Gene