Gene: Nsd3

Order

Name nuclear receptor binding SET domain protein 3

Synonyms
  • Whsc1l1
  • WHISTLE

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:2142581    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Subviable

Phenotype associations for Nsd3

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Nsd3 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, incomplete penetrance Nsd3tm1b(EUCOMM)Hmgu HOM Female Male n/a 0.0
small spleen Nsd3tm1b(EUCOMM)Hmgu HOM Male postnatal 0.0
increased startle reflex Nsd3tm1b(EUCOMM)Hmgu HOM Female Male postnatal 4.76E-10
trunk curl Nsd3tm1b(EUCOMM)Hmgu HET Female postnatal 1.5E-8
decreased prepulse inhibition Nsd3tm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.78E-6
tremors Nsd3tm1b(EUCOMM)Hmgu HET Female Male postnatal 5.23E-6
increased startle reflex Nsd3tm1b(EUCOMM)Hmgu HET Female Male postnatal 8.55E-6
abnormal behavior Nsd3tm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.08E-5
decreased fasted circulating glucose level Nsd3tm1b(EUCOMM)Hmgu HET Male postnatal 3.37E-5
impaired glucose tolerance Nsd3tm1b(EUCOMM)Hmgu HOM Female Male postnatal 4.34E-5
increased total body fat amount Nsd3tm1b(EUCOMM)Hmgu HET Female Male postnatal 6.21E-5
short tibia Nsd3tm1b(EUCOMM)Hmgu HET Female postnatal 8.12E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393) (2/2)
Aorta 2 No (1/562) (2/2)
Bone 2 No (1/539) (2/2)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562) (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562) (2/2)
Cerebellum 2 No (4/562) (2/2)
Cerebral cortex 2 No (5/562) (2/2)
Esophagus 2 No (2/393) (2/2)
Eye 2 No (1/562) (2/2)
Gall bladder 2 No (2/2)
Heart 2 No (3/562) (2/2)
Hippocampus 2 No (5/562) (2/2)
Hypothalamus 2 No (4/562) (2/2)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562) (2/2)
Liver 2 No (2/2)
Lower urinary tract 2 No (3/562) (2/2)
Lung 2 No (3/562) (2/2)
Lymph node 2 No (1/562) (2/2)
Mammary gland 2 No
Olfactory lobe 2 No (4/393) (2/2)
Oral epithelium 2 No (2/2)
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562) (2/2)
Parathyroid gland 2 No (2/540) (2/2)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No (1/393) (2/2)
Pituitary gland 2 No (1/562) (2/2)
Prostate gland 2 No (5/562) (1/2)
Skeletal muscle 2 No
Skin 2 No (1/562) (2/2)
Small intestine 2 No (11/562) (2/2)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562) (1/2)
Stomach 2 No (9/562) (2/2)
Striatum 2 No (4/562) (2/2)
Testis 2 No (4/562) (1/2)
Thymus 2 No (2/2)
Thyroid gland 2 No (16/562) (2/2)
Trachea 2 No (3/562) (2/2)
Uterus 2 No (2/562) (1/2)
Vascular system 2 No (1/393) (2/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    musculoskeletal system
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/482) (4/4)
Ear 2 (1/482) (4/4)
Embryo 2 (1/482) (4/4)
Eye 2 (1/482) (2/4)
Foot 2 (1/482) (4/4)
Forebrain 2 (1/482) (4/4)
Forelimb 2 (1/482) (4/4)
Hand 2 (1/482) (4/4)
Head 2 (5/482) (4/4)
Heart 2 (1/482) (2/4)
Hindbrain 2 (6/482) (4/4)
Hindlimb 2 (1/482) (4/4)
Liver 2 (1/482) (2/4)
Lung 2 (1/482) (2/4)
Mandibular process 2 (1/482) (2/4)
Maxillary process 2 (1/482) (2/4)
Midbrain 2 (1/482) (4/4)
Oral cavity 2 (1/482) (2/4)
Skin 2 (1/482) (2/4)
Tail 2 (1/482) (4/4)
Tail somite 2 (1/482) (4/4)


Associated Images

Associated Images
  • Echo: M-Mode Images
    52 Images
  • X-ray: XRay Images Dorso Ventral
    18 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    16 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    8 Images
  • Adult LacZ: LacZ Images Wholemount
    25 Images
  • X-ray: XRay Images Lateral Orientation
    17 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Nsd3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Nsd3tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Nsd3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene