Gene: Dhodh

Order

Name dihydroorotate dehydrogenase

Synonyms 2810417D19Rik

Status ES CellsMice
tm1b
Mice
tm1a
phenotype data available

Links MGI:1928378    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Dhodh

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Dhodh data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
embryonic lethality prior to organogenesis Dhodhtm1b(EUCOMM)Wtsi HOM Female Male embryonic day 9.5 0.0
prenatal lethality prior to heart atrial septation Dhodhtm1b(EUCOMM)Wtsi HOM Female Male embryonic day 14.5 0.0
preweaning lethality, complete penetrance Dhodhtm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/2)
Aorta 2 No (1/562) (2/2)
Blood vessel 2 No
Bone 2 No (1/539)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562) (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562) (2/2)
Cerebral cortex 2 No (5/562) (2/2)
Eye 2 No (1/562)
Gall bladder 2 No
Heart 2 No (3/562)
Hippocampus 2 No (5/562) (2/2)
Hypothalamus 2 No (4/562) (2/2)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Esophagus 2 No
Olfactory lobe 2 No (2/2)
Ovary 2 No (1/562)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540) (2/2)
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No
Pituitary gland 2 No (1/562) (2/2)
Prostate gland 2 No (5/562)
Skeletal muscle tissue 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562)
Stomach 2 No (9/562)
Striatum 2 No (4/562) (2/2)
Testis 2 No (4/562) (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562) (2/2)
Uterus 2 No (2/562)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system postnatal mouse respiratory system cardiovascular system nervous system reproductive system trunk urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (11)
  • Dhodhtm1b(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    oviduct, HET, Female, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    testis, HET, Female, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    brainstem, HET, Female, WTSI

show all 11 images

trunk (7)
  • Dhodhtm1b(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    oviduct, HET, Female, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    testis, HET, Female, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    kidney, HET, Female, WTSI

show all 7 images

nervous system (4)
  • Dhodhtm1b(EUCOMM)Wtsi
    brainstem, HET, Female, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    spinal cord, HET, Female, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    pituitary gland, HET, Female, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    cerebral cortex, HET, Female, WTSI
endocrine system (2)
  • Dhodhtm1b(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    parathyroid gland, HET, Female, WTSI
reproductive system (2)
  • Dhodhtm1b(EUCOMM)Wtsi
    oviduct, HET, Female, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    testis, HET, Female, WTSI
urinary system (2)
  • Dhodhtm1b(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    kidney, HET, Female, WTSI
cardiovascular system (1)
  • Dhodhtm1b(EUCOMM)Wtsi
    aorta, HET, Female, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Forepaw
    14 Images
  • X-ray: XRay Images Lateral Orientation
    28 Images
  • X-ray: XRay Images Skull Lateral Orientation
    14 Images
  • X-ray: XRay Images Dorso Ventral
    42 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    14 Images
  • Anti-nuclear antibody assay
    6 Images
  • DSS Histology
    6 Images
Legacy Phenotype Associated Images
Xray (85)
  • Dhodhtm1b(EUCOMM)Wtsi
    HET, Male, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    HET, Male, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    HET, Male, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    HET, Male, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    HET, Male, WTSI

show all 85 images

Histology Slide (5)
  • Dhodhtm1b(EUCOMM)Wtsi
    TS20 eye, HET, Female, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    TS20 chorioallantoic placenta, HET, Female, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    TS20 liver, HET, Male, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    TS20 stomach, HET, Male, WTSI
  • Dhodhtm1b(EUCOMM)Wtsi
    TS20 midbrain, TS20 brain, HET, Female, WTSI
Dysmorphology (1)
  • Dhodhtm1b(EUCOMM)Wtsi
    head, abnormal snout morphology, HET, Female, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Dhodhtm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Dhodhtm83184(L1L2_Bact_P)
Vector
Gene
Dhodhtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Dhodhtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene