Gene: Ints12

Order

Name integrator complex subunit 12

Synonyms
  • 2810027J24Rik
  • A230056J18Rik
  • Phf22
  • 4930529N21Rik
  • 1110020M19Rik

Status ES CellsMice
tm1a
Mice
tm1b
Mice
tm1c
phenotype data available

Links MGI:1919043    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Ints12

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Ints12 data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Ints12tm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0
preweaning lethality, complete penetrance Ints12tm1a(EUCOMM)Wtsi HOM Female Male n/a 0.0
decreased red blood cell distribution width Ints12tm1b(EUCOMM)Wtsi HET Male postnatal 3.87E-7
increased circulating magnesium level Ints12tm1a(EUCOMM)Wtsi HET Female postnatal 1.93E-5
decreased mean corpuscular volume Ints12tm1b(EUCOMM)Wtsi HET Female Male postnatal 4.06E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/2)
Adrenal gland 2 No (5/393) (2/2)
Aorta 4 No (1/562) (2/4)
Blood vessel 2 No
Bone 4 No (1/539)
Brain 4 No (6/562) (4/4)
Brainstem 4 No (4/562) (2/4)
Brown adipose tissue 2 No
Brown adipose tissue 2 No
Cartilage tissue 4 No (1/562) (4/4)
Cerebellum 4 No (4/562) (2/4)
Cerebral cortex 4 No (5/562) (2/4)
Esophagus 2 No (2/393) (2/2)
Eye 4 No (1/562) (2/4)
Gall bladder 4 No (2/4)
Heart 4 No (3/562) (4/4)
Hippocampus 4 No (5/562) (2/4)
Hypothalamus 4 No (4/562) (2/4)
Kidney 4 No (20/562) (2/4)
Large intestine 4 No (12/562) (3/4)
Liver 4 No (1/4)
Lower urinary tract 4 No (3/562) (3/4)
Lung 4 No (3/562) (4/4)
Lymph node 4 No (1/562) (1/4)
Mammary gland 4 No (1/4)
Esophagus 2 No (2/2)
Olfactory lobe 2 No (4/393) (2/2)
Olfactory lobe 2 No
Oral epithelium 2 No
Ovary 4 No (1/562) (2/4)
Oviduct 4 No (2/562) (2/4)
Pancreas 4 No (6/562) (1/4)
Parathyroid gland 4 No (2/540) (3/4)
Peripheral nervous system 4 No (3/562) (4/4)
Peyer's patch 2 No
Peyer's patch 2 No (1/393) (2/2)
Pituitary gland 4 No (1/562) (3/4)
Prostate gland 4 No (5/562)
Skeletal muscle 2 No (2/2)
Skeletal muscle tissue 2 No (2/2)
Skin 4 No (1/562) (2/4)
Small intestine 4 No (11/562) (4/4)
Spinal cord 4 No (3/562) (4/4)
Spleen 4 No (4/562) (2/4)
Stomach 4 No (9/562) (3/4)
Striatum 4 No (4/562) (2/4)
Testis 4 No (4/562) (2/4)
Thymus 4 No (2/4)
Thyroid gland 4 No (16/562) (2/4)
Trachea 4 No (3/562) (4/4)
Uterus 4 No (2/562) (2/4)
Vascular system 2 No (1/393) (2/2)
White adipose tissue 4 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    musculoskeletal system
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 3 (6/482) (1/3)
Ear 3 (1/482) (1/3)
Embryo 3 (1/482) (3/3)
Eye 3 (1/482) (1/3)
Foot 3 (1/482) (1/3)
Forebrain 3 (1/482) (1/3)
Forelimb 3 (1/482) (3/3)
Hand 3 (1/482) (1/3)
Head 3 (5/482) (3/3)
Heart 3 (1/482) (1/3)
Hindbrain 3 (6/482) (1/3)
Hindlimb 3 (1/482) (3/3)
Liver 3 (1/482) (1/3)
Lung 3 (1/482) (1/3)
Mandibular process 3 (1/482) (1/3)
Maxillary process 3 (1/482) (1/3)
Midbrain 3 (1/482) (1/3)
Oral cavity 3 (1/482) (1/3)
Skin 3 (1/482) (3/3)
Tail 3 (1/482) (3/3)
Tail somite 3 (1/482) (1/3)


Secondary lacZ Expression Data
postnatal mouse (20)
  • Ints12tm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    skeletal muscle tissue, HET, Male, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    lower urinary tract, urinary bladder, HET, Male, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    stomach, HET, Female, WTSI

show all 20 images

trunk (13)
  • Ints12tm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    lower urinary tract, urinary bladder, HET, Male, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    stomach, HET, Female, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI

show all 13 images

nervous system (4)
  • Ints12tm1a(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    pituitary gland, peripheral nervous system, HET, Female, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    spinal cord, HET, Male, WTSI
digestive system (3)
  • Ints12tm1a(EUCOMM)Wtsi
    stomach, HET, Female, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    small intestine, HET, Female, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    large intestine, HET, Male, WTSI
endocrine system (2)
  • Ints12tm1a(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    parathyroid gland, HET, Female, WTSI
immune system (2)
  • Ints12tm1a(EUCOMM)Wtsi
    spleen, HET, Female, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    thymus, HET, Female, WTSI
musculoskeletal system (2)
  • Ints12tm1a(EUCOMM)Wtsi
    skeletal muscle tissue, HET, Male, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    skeletal muscle tissue, HET, Female, WTSI
reproductive system (2)
  • Ints12tm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    oviduct, HET, Female, WTSI
urinary system (2)
  • Ints12tm1a(EUCOMM)Wtsi
    lower urinary tract, urinary bladder, HET, Male, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    kidney, HET, Male, WTSI
cardiovascular system (1)
  • Ints12tm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
integumental system (1)
  • Ints12tm1a(EUCOMM)Wtsi
    skin, HET, Female, WTSI
respiratory system (1)
  • Ints12tm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI

Associated Images

Associated Images
  • Echo: M-Mode Images
    32 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • Embryo LacZ: LacZ images wholemount
    4 Images
  • Adult LacZ: LacZ Images Wholemount
    23 Images
Legacy Phenotype Associated Images
Xray (96)
  • Ints12tm1a(EUCOMM)Wtsi
    forearm, WT, Male, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    body, WT, Male, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    head, WT, Male, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    body, HET, Male, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    head, HET, Male, WTSI

show all 96 images

Skin Histopathology (4)
  • Ints12tm1a(EUCOMM)Wtsi
    back skin, HET, Female, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    back skin, HET, Female, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    back skin, HET, Female, WTSI
  • Ints12tm1a(EUCOMM)Wtsi
    back skin, HET, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Ints12tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Ints12tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Ints12tm1c(EUCOMM)Wtsi Wild type floxed exon (post-Flp)
Vector
Gene