Gene: Exosc8

Order

Name exosome component 8

Synonyms 2310032N20Rik

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:1916889    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Exosc8

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Exosc8 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
embryonic lethality prior to tooth bud stage Exosc8tm1.1(KOMP)Vlcg HOM Female Male embryonic day 12.5 0.0
preweaning lethality, complete penetrance Exosc8tm1.1(KOMP)Vlcg HOM Female Male n/a 0.0
thrombocytopenia Exosc8tm1.1(KOMP)Vlcg HET Male postnatal 6.93E-8

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415) (2/2)
Aorta 2 No (2/2)
Bone 2 No (2/2)
Brain 2 No (2/2)
Brainstem 2 No (2/2)
Brown adipose tissue 2 No (2/2)
Cartilage tissue 2 No
Cerebellum 2 No (2/2)
Cerebral cortex 2 No (2/2)
Epididymis 2 No (18/134)
Esophagus 2 No (7/415) (2/2)
Eye 2 No (2/2)
Heart 2 No (2/2)
Hippocampus 2 No (2/2)
Hypothalamus 2 No (2/2)
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No (2/2)
Lower urinary tract 2 No
Lung 2 No (2/2)
Lymph node 2 No (2/2)
Mammary gland 2 No (1/2)
Midbrain 2 No (2/2)
Olfactory lobe 2 No (2/2)
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584) (2/2)
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No (2/2)
Prostate gland 2 No (12/584)
Skeletal muscle 2 No
Skin 2 No (2/2)
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584) (2/2)
Stomach 2 No (12/584) (2/2)
Striatum 2 No (2/2)
Submandibular gland 2 No (2/132) (2/2)
Testis 2 No (2/584) (1/2)
Thalamus 2 No (2/2)
Thymus 2 No (2/2)
Thyroid gland 2 No (15/584) (2/2)
Trachea 2 No (2/2)
Urinary bladder 2 No (2/2)
Uterus 2 No (1/2)
Vascular system 2 No
Vesicular gland 2 No
White adipose tissue 2 No (2/2)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues reproductive system adipose tissue musculoskeletal system trunk postnatal mouse nervous system sensory organ immune system exocrine system integumental system urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 1 (1/51) (1/1)
Brain 1 (6/485) (1/1)
Ear 1 (1/485) (1/1)
Embryo 1 (1/485) (1/1)
Eye 1 (1/485)
Foot 1 (1/485) (1/1)
Forebrain 1 (1/485) (1/1)
Forelimb 1 (1/485) (1/1)
Hand 1 (1/485) (1/1)
Head 1 (5/485) (1/1)
Heart 1 (1/485) (1/1)
Hindbrain 1 (6/485) (1/1)
Hindlimb 1 (1/485) (1/1)
Liver 1 (1/485) (1/1)
Lung 1 (1/485)
Mandibular process 1 (1/485) (1/1)
Maxillary process 1 (1/485) (1/1)
Midbrain 1 (1/485) (1/1)
Nose 1 (1/51) (1/1)
Oral cavity 1 (1/485) (1/1)
Skeleton 1 (1/51) (1/1)
Skin 1 (1/485) (1/1)
Tail 1 (1/485) (1/1)
Tail somite 1 (1/485)
Umbilical artery embryonic part 1 (1/47) (1/1)
Umbilical vein embryonic part 1 (1/47) (1/1)


Associated Images

Associated Images
  • X-ray: XRay Images Skull Lateral Orientation
    9 Images
  • X-ray: XRay Images Dorso Ventral
    9 Images
  • X-ray: XRay Images Lateral Orientation
    9 Images
  • Electroretinography: Cone waveform (pdf format)
    3 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    9 Images
  • X-ray: XRay Images Forepaw
    9 Images
  • Embryo LacZ: LacZ images wholemount
    8 Images
  • Electroretinography: Rod waveform (pdf format)
    3 Images
  • Sleep Wake: Wake state (bmp file)
    3 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Exosc8tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Exosc8tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Exosc8tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Exosc8tm47080(L1L2_gt0)
Vector
Gene