Gene: Arhgef12

Order

Name Rho guanine nucleotide exchange factor (GEF) 12

Synonyms
  • LARG
  • 2310014B11Rik

Status ES CellsMice
tm1b
Mice
tm1a
phenotype data available

Links MGI:1916882    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Subviable

Phenotype associations for Arhgef12

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Arhgef12 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal embryo size Arhgef12tm1b(KOMP)Wtsi HOM Male embryonic day 9.5 0.0
abnormal embryo size Arhgef12tm1b(KOMP)Wtsi HET Female Male embryonic day 9.5 0.0
embryonic growth retardation Arhgef12tm1b(KOMP)Wtsi HOM Male embryonic day 9.5 0.0
embryonic growth retardation Arhgef12tm1b(KOMP)Wtsi HET Female Male embryonic day 9.5 0.0
prenatal lethality prior to heart atrial septation Arhgef12tm1b(KOMP)Wtsi HOM Female Male embryonic day 14.5 0.0
preweaning lethality, incomplete penetrance Arhgef12tm1b(KOMP)Wtsi HOM Female Male n/a 0.0
abnormal sensory capabilities/reflexes/nociception Arhgef12tm1b(KOMP)Wtsi HET Female Male postnatal 5.31E-9
decreased mean corpuscular hemoglobin Arhgef12tm1b(KOMP)Wtsi HET Female Male postnatal 5.87E-6

Download data as: TSV XLS



Expression

Expression data not available

Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Arhgef12tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Fixed Tissue
Paraffin-embedded Sections
Arhgef12tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene