Gene: Arhgef1

Order

Name Rho guanine nucleotide exchange factor (GEF) 1

Synonyms
  • Lsc
  • Lbcl2

Status ES CellsMice
tm1a
phenotype data available

Links MGI:1353510    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Subviable

Phenotype associations for Arhgef1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Arhgef1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased CD8-positive, alpha-beta T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased Ly6C-positive immature NK cell number Arhgef1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased dendritic cell number Arhgef1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased immature NK cell number Arhgef1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased marginal zone B cell number Arhgef1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased memory-marker CD4-positive NK T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased memory-marker gamma-delta T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased CD4-positive, alpha beta T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased KLRG1-positive NK cell number Arhgef1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased Ly6C low monocyte number Arhgef1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased Ly6C-positive NK T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased effector memory CD4-positive, alpha-beta T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased effector memory CD8-positive, alpha-beta T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased gamma-delta T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased mature NK cell number Arhgef1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased monocyte cell number Arhgef1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased plasmacytoid dendritic cell number Arhgef1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
preweaning lethality, incomplete penetrance Arhgef1tm1a(EUCOMM)Wtsi HOM Female Male n/a 0.0

Download data as: TSV XLS



Expression

Expression data not available

Associated Images

Associated Images
  • Mesenteric Lymph Node Immunophenotyping: Images associated with FACS analysis
    36 Images
  • Anti-nuclear antibody assay
    10 Images
  • Spleen Immunophenotyping: Images associated with FACS analysis
    64 Images
  • DSS Histology
    8 Images
Legacy Phenotype Associated Images
Eye Morphology (4)
  • Arhgef1tm1a(EUCOMM)Wtsi
    fused cornea and lens, HOM, Female, WTSI
  • Arhgef1tm1a(EUCOMM)Wtsi
    persistence of hyaloid vascular system, HOM, Female, WTSI
  • Arhgef1tm1a(EUCOMM)Wtsi
    mydriasis, HOM, Female, WTSI
  • Arhgef1tm1a(EUCOMM)Wtsi
    abnormal cornea morphology, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Arhgef1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene