Gene: Ap2a2

Order

Name adaptor-related protein complex 2, alpha 2 subunit

Synonyms
  • Adtab
  • alpha-C adaptin
  • alpha-adaptin C
  • L25
  • 2410074K14Rik

Status ES CellsMice
tm1a
Mice
tm1b
Mice
em1
phenotype data available

Links MGI:101920    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable     Homozygous - Subviable

Phenotype associations for Ap2a2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Ap2a2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, incomplete penetrance Ap2a2em1(IMPC)Wtsi HOM Female Male n/a 0.0
absent pinna reflex Ap2a2tm1b(EUCOMM)Wtsi HOM Female postnatal 2.7E-9
increased circulating LDL cholesterol level Ap2a2em1(IMPC)Wtsi HET Male postnatal 1.07E-8
increased circulating cholesterol level Ap2a2em1(IMPC)Wtsi HET Male postnatal 3.5E-5
increased circulating HDL cholesterol level Ap2a2em1(IMPC)Wtsi HET Male postnatal 4.97E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/2)
Aorta 2 No (1/562) (2/2)
Blood vessel 2 No
Bone 2 No (1/539) (2/2)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562) (2/2)
Brown adipose tissue 2 No (2/2)
Cartilage tissue 2 No (1/562) (2/2)
Cerebellum 2 No (4/562) (2/2)
Cerebral cortex 2 No (5/562) (2/2)
Eye 2 No (1/562) (2/2)
Gall bladder 2 No (1/2)
Heart 2 No (3/562) (2/2)
Hippocampus 2 No (5/562) (2/2)
Hypothalamus 2 No (4/562) (2/2)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562) (2/2)
Liver 2 No
Lower urinary tract 2 No (3/562) (2/2)
Lung 2 No (3/562) (2/2)
Lymph node 2 No (1/562) (2/2)
Mammary gland 2 No
Esophagus 2 No (2/2)
Olfactory lobe 2 No (2/2)
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562) (2/2)
Parathyroid gland 2 No (2/540) (2/2)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No (2/2)
Pituitary gland 2 No (1/562) (1/2)
Prostate gland 2 No (5/562) (1/2)
Skeletal muscle tissue 2 No
Skin 2 No (1/562) (2/2)
Small intestine 2 No (11/562) (2/2)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562)
Stomach 2 No (9/562) (2/2)
Striatum 2 No (4/562) (2/2)
Testis 2 No (4/562) (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562) (2/2)
Trachea 2 No (3/562) (2/2)
Uterus 2 No (2/562) (1/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues reproductive system musculoskeletal system adipose tissue trunk postnatal mouse nervous system sensory organ immune system exocrine system integumental system urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (22)
  • Ap2a2tm1b(EUCOMM)Wtsi
    heart, aorta, HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    spinal cord, HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    oesophagus, HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    brown adipose tissue, HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    parathyroid gland, HET, Female, WTSI

show all 22 images

trunk (15)
  • Ap2a2tm1b(EUCOMM)Wtsi
    heart, aorta, HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    spinal cord, HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    oesophagus, HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI

show all 15 images

digestive system (4)
  • Ap2a2tm1b(EUCOMM)Wtsi
    oesophagus, HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    small intestine, HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    large intestine, HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    gall bladder, HET, Male, WTSI
nervous system (3)
  • Ap2a2tm1b(EUCOMM)Wtsi
    spinal cord, HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    trigeminal V nerve, peripheral nervous system, HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    brain, HET, Male, WTSI
urinary system (3)
  • Ap2a2tm1b(EUCOMM)Wtsi
    kidney, HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Male, WTSI
endocrine system (2)
  • Ap2a2tm1b(EUCOMM)Wtsi
    parathyroid gland, HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
reproductive system (2)
  • Ap2a2tm1b(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    uterus, HET, Female, WTSI
set of connective tissues (2)
  • Ap2a2tm1b(EUCOMM)Wtsi
    brown adipose tissue, HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    cartilage tissue, rib, HET, Female, WTSI
adipose tissue (1)
  • Ap2a2tm1b(EUCOMM)Wtsi
    brown adipose tissue, HET, Female, WTSI
cardiovascular system (1)
  • Ap2a2tm1b(EUCOMM)Wtsi
    heart, aorta, HET, Female, WTSI
immune system (1)
  • Ap2a2tm1b(EUCOMM)Wtsi
    lymph node, mesenteric lymph node, HET, Female, WTSI
integumental system (1)
  • Ap2a2tm1b(EUCOMM)Wtsi
    skin, HET, Female, WTSI
musculoskeletal system (1)
  • Ap2a2tm1b(EUCOMM)Wtsi
    cartilage tissue, rib, HET, Female, WTSI
respiratory system (1)
  • Ap2a2tm1b(EUCOMM)Wtsi
    lung, HET, Female, WTSI
sensory organ (1)
  • Ap2a2tm1b(EUCOMM)Wtsi
    eye, HET, Female, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    65 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    32 Images
  • X-ray: XRay Images Dorso Ventral
    85 Images
  • X-ray: XRay Images Forepaw
    33 Images
  • X-ray: XRay Images Skull Lateral Orientation
    32 Images
  • Eye Morphology: Images Slit Lamp
    1 Images
  • Anti-nuclear antibody assay
    6 Images
  • DSS Histology
    12 Images
Legacy Phenotype Associated Images
Xray (165)
  • Ap2a2tm1b(EUCOMM)Wtsi
    HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    HET, Female, WTSI

show all 165 images

Histology Slide (5)
  • Ap2a2tm1b(EUCOMM)Wtsi
    TS20 stomach, HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    TS20 chorioallantoic placenta, HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    TS20 forebrain, TS20 oral cavity, TS20 mandibular process, TS20 ear, TS20 skin, TS20 brain, TS20 hindbrain, TS20 maxillary process, TS20 tongue, HET, Male, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    TS20 liver, HET, Female, WTSI
  • Ap2a2tm1b(EUCOMM)Wtsi
    TS20 head, HET, Male, WTSI
Dysmorphology (1)
  • Ap2a2em1(IMPC)Wtsi
    abnormal ventral coat pigmentation, abnormal coat/hair pigmentation, WT, Male, WTSI
Embryo Dysmorphology (1)
  • Ap2a2tm1b(EUCOMM)Wtsi
    HOM, Unsexed, WTSI
Eye Morphology (1)
  • Ap2a2tm1b(EUCOMM)Wtsi
    corneal opacity, HET, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Ap2a2tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Ap2a2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Ap2a2em1(IMPC)Wtsi Exdel
Vector
Gene
Ap2a2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene